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Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. Fluconazole is a triazole antifungal agent that can be administered orally or parenterally. Your doctor if you have liver disease, kidney disease, or a heart rhythm disorder. Fluconazole is a very widely used antifungal agent. Fluconazole works best if it is taken at the same time each day.
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