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Although side effects from Premarin are not common, they can occur. Estrogens may increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Stop taking this medication and call your doctor at once if you have had any circulation problem involving blood clots. Before using conjugated estrogens. Long-term treatment with conjugated estrogens may increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus.
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